Primary hyperaldosteronism

Gautam Panduranga, Rajesh Lekkala, Veera Chanukya Griddaluru, Sujatha K

Pdf Page Numbers :- 18-21

 Gautam Panduranga^1,*, Rajesh Lekkala¹, Veera Chanukya Griddaluru² and Sujatha K³

¹Department of Internal Medicine, Krishna Institute of Medical Sciences, Minister Road, Secunderabad-500003, Telangana, India

²Department of Endocrinology, Krishna Institute of Medical Sciences, Minister Road, Secunderabad-500003, Telangana, India

³Department of Pathology, Krishna Institute of Medical Sciences, Minister Road, Secunderabad-500003, Telangana, India

*Corresponding author: Dr. Gautam Panduranga, MD, ABIM., Consultant Physician, Department of Internal Medicine, Krishna Institute of Medical Sciences, Minister Road, Secunderabad-500003, Telangana, India. Mobile: +91 9676317821; Email: gautampsetty@yahoo.com

Received 25 September 2015; Revised 30 November 2015; Accepted 9 December 2015; Published 18 December 2015

Citation: Panduranga G, Lekkala R, Griddaluru VC, Sujatha K. Primary hyperaldosteronism. J Med Sci Res. 2016; 4(1):18-21. DOI: http://dx.doi.org/10.17727/JMSR.2016/4-006

Copyright: © 2016 Panduranga G, et al. Published by KIMS Foundation and Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Abstract

 Primary aldosteronism is caused by autonomous production of aldosterone by the adrenal cortex (due to hyperplasia, adenoma, or carcinoma). It is the cause of most common secondary form of arterial hypertension. The most common causes (90%) of primary aldosteronism are aldosterone producing adenomas and bilateral adrenal hyperplasia. Surgery is the recommended treatment for aldosterone producing adenomas. A 48-year-old woman, known hypertensive, was admitted with severe and refractory hypokalemia, ECG abnormalities and metabolic alkalosis. Serum aldosterone to PRA (plasma renin activity) ratio was high and CT scan of abdomen revealed an adrenal adenoma. She underwent left laparoscopic adrenalectomy and histopathology confirmed the presence of adrenal adenoma. Both hypertension and hypokalemia resolved after surgery. High degree of suspicion is required to recognize this disorder early and to arrange proper diagnostic tests and treatment, to avoid missing curable hypertension

Keywords: Hypertension; hypokalemia; primary aldosteronism; Conn’s syndrome