Correlation of NT-proBNP levels with clinical and echocardiographic features in evaluation of patients admitted with heart failure

Dhinakaran K, Selvarajan N

Pdf Page Numbers :- 275-279

Krishnamurthy Dhinakaran^1,* and Nagendran Selvarajan²

¹Department of Cardiology, AMC Super Speciality Hospitals, Tirupur, Tamil Nadu 641604, India

²Department of Bio-statistics, AMC Super Speciality Hospitals, Tirupur, Tamil Nadu 641604, India

*Corresponding author: Dr. Dhinakaran Krishnamurthy, DNB (Med), DNB (Cardiology), Consultant Cardiologist, Department of Cardiology, AMC Super Speciality Hospitals, Tirupur, Tamil Nadu 641604, India. Email: krishnavasanth2000@yahoo.com

Received 21 June 2023; Revised 22 August 2023; Accepted 30 August 2023; Published 4 September 2023

Citation: Dhinakaran K, Selvarajan N. Correlation of NT-proBNP levels with clinical and echocardiographic features in evaluation of patients admitted with heart failure. J Med Sci Res. 2023; 11(4):275-279. DOI: http://dx.doi.org/10.17727/JMSR.2023/11-51

Copyright: © 2023 Dhinakaran K et al. Published by KIMS Foundation and Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Abstract

Background: Heart failure (HF) is one of the leading causes of hospitalizations in both developed as well as developing nations. The natriuretic peptide N-terminal pro-BNP (NT-proBNP) has long been used for diagnosing and managing HF. The study aimed to determine the correlation of NT-proBNP levels with clinical and echocardiographic features in evaluation of patients admitted with heart failure.

Methods: This is retrospective observational study of 37 patients admitted to the hospital with acute onset dyspnea, over a period of 18 months. In addition to detailed history and physical examination, complete blood counts, random blood sugar, blood biochemistry, and electrocardiography (ECG), bedside echocardiography and x-ray chest were performed on admission to the hospital. Measurement of serum NT-proBNP level was performed as part of evaluation of dyspnea.

Results: Average age of the study population was 64 years. The co morbidities among the patients were hypertension (91%), diabetes mellitus (68%), obstructive airway disease (21%), coronary artery disease (16%) and chronic kidney disease (4%). The mean NT-proBNP for each group was LVEF ≥ 50%= 2272, LVEF 40–49% = 8161.5, and LVEF < 40% = 17302.7 (pg/ml).

Conclusion: NT-proBNP levels are proven to be useful in diagnosing and management of heart failure. However, the levels can be affected by many factors such as age, renal function, anaemia and body mass. When interpreting NT-proBNP levels, these factors have to be taken into account while making clinical decision and initiation of appropriate therapy.

Keywords: heart failure; natriuretic peptides; NT- proBNP; hypertension