Case Report
2019
March
Volume : 7
Issue : 1
A rare case of hemophagocytic lymphohistiocytosis triggered by disseminated tuberculosis
Avinash RM, Nagendra D, Ashraf Ali P, Manmadharao T
Pdf Page Numbers :- 11-13
Avinash RM1,*, Nagendra D1, Ashraf Ali P1 and Manmadharao T1
1Department of Pulmonology, Krishna Institute of Medical Sciences, Minister Road, Secunderabad-500003, Telangana, India
*Corresponding author: Avinash RM, Department of Pulmonology, Krishna Institute of Medical Sciences, Minister Road, Secunderabad-500003, Telangana, India. Email: avinash.rm1993@gmail.com
Received 29 August 2018; Revised 12 November 2018; Accepted 20 November 2018; Published 03 December 2018
Citation: Avinash RM, Nagendra D, Ali AP, Manmadharao T. A rare case of hemophagocytic lymphohistiocytosis triggered by disseminated tuberculosis. J Med Sci Res. 2019; 7(1):11-13. DOI: http://dx.doi.org/10.17727/JMSR.2019/7-3
Copyright: © 2019 Avinash RM et al. Published by KIMS Foundation and Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract
Hemophagocytic lymphohistiocytosis (HLH) is an uncommon, life threatening hyperinflammatory syndrome caused by severe hypercytokinemia due to highly stimulated but ineffective immune process, leading to phagocytosis of erythrocytes, leukocytes, platelets and their precursors in bone marrow and other tissues by macrophages. There are two types, which are primary HLH and secondary HLH. HLH is a potentially treatable condition which is often missed due to lack of suspicion, variable and nonspecific presentations and inability to fulfill all the diagnostic criteria. Prompt initiation of immunochemotherapy is essential but timely diagnosis may be challenging, because of rarity of HLH. We report a case of secondary HLH in 62-year-old female, triggered by disseminated tuberculosis.
Keywords: Hemophagocytic lymphohistiocytosis; phagocytosis; disseminated tuberculosis